Correlation between HLA-Cw*0602 and LCE3B_LCE3C-del allele interaction and psoriasis vulgaris in a population of Mongolian nationality in Inner Mongolia / 中国基层医药

Objective:To investigate the effect of HLA-Cw*0602 and LCE3B_LCE3C-del allele interaction on the risk of psoriasis vulgaris in a population of Mongolian nationality in Inner Mongolia. Methods:A total of 365 Mongolian patients with psoriasis vulgaris who received treatment in The Affiliated Hospital of Inner Mongolia Medical University from January 2006 to December 2015 (case group) and 284 healthy subjects who concurrently received physical examination in the same hospital (control group) were included in this study. After sex and age matching, and quality control, the correlations between HLA-Cw*0602 and LCE3B_LCE3C-del allele and psoriasis vulgaris in a population of Mongolian nationality were analyzed using SPSS 20.0 software. The interaction between HLA-Cw*0602 and LCE3B_LCE3C-del alleles (adjusting for potential confounders including age and sex) was analyzed using logistic regression. Results:Logistic regression interaction item Int of dominant inheritance mode HLA-Cw*0602 allele and recessive inheritance mode LCE3C_LCE3B-del allele revealed OR = 2.38, P = 0.033, and interaction index S = 1.21, indicating that there was a synergistic effect between the two alleles. Conclusion:The co-existence of HLA-Cw*0602 and LCE3B_LCE3C-del may increase the risk of psoriasis vulgaris in a population of Mongolian nationality in Inner Mongolia.

Feedforward control of academic misconducts theses in sci-tech periodicals / 中华医学科研管理杂志

Objective To prevent the occurrence of academic misconduct in sci-tech periodicals from the source.Methods Based on the control theory in modern management,the method of inductive analysis was adopted.Results To define the feedforward control of academic misconduct in sci-tech periodicals,identify three-level feedforward control that including author,author's institution and the sci-tech periodical editor.Conclusions Three level feedforward control is an effective way to prevent academic misconduct.

A randomized controlled study of peramivir, oseltamivir and placebo in patients with mild influenza / 中华内科杂志

Objectives To evaluate the effectiveness and safety of peramivir trihydrate in patients with influenza.Methods This was a randomized,double-blind,double-dummy,placebo and positive control,multicenter clinical trial,comparing peramivir trihydrate with oseltamivir and placebo.The inclusive criteria were 15-70 years old,onset within 48 h,positive rapid influenza antigen test,and febrile(＞38℃) accompanied with at least two associated symptoms.The severe cases complicated with chronic pulmonary and cardiac diseases,malignancies,organ transplantation,hemodialysis,uncontrolled diabetes,immunocompromised status,pregnancy and coexistence of bacterium infections were excluded.All patients were randomized 2:2:1 to receive peramivir,oseltamivir and placebo respectively.The primary endpoint was the disease duration,the secondary endpoints included time to normal axillary temperature and normal living activities,viral response,and adverse effects.Results Following informed consent,133 patients were included in this study.Four patients were exclude due to missing medical records,not fitting inclusion or exclusion criteria and poor compliance.A total of 129 patients were finally analyzed,including 49 cases,54 cases and 26 cases in peramivir group,oseltamivir group and placebo group.The median disease duration were 96 (76,120)hours,105(90,124) hours,and 124 (104,172)hours in three groups respectively(P＞0.05).The time to normal axillary temperature,normal living activities and viral response were not significantly different in three groups(P＞0.05).Conclusion The value of antiviral therapy in patients with mild influenza needs to be further determined.

Juristic responsibility of academic misconduct and countermeasure analysis / 中华医学科研管理杂志

Objective Discussing the Juristic Responsibility of academic misconduct and possible countermeasures.Methods This thesis uses of empirical study to analyze the juristic responsibility of academic misconduct,tried to identify the legal liabilities of the people directly involved.Results If the consequences of academic misconduct is not serious,the people who committed should take the administrative responsibility;if the academic misconduct is related to civil liability or criminal responsibility,related person also need to bear the corresponding civil and criminal responsibilities besides the administrative responsibility.Conclusions The effectual approaches to reduce the academic misconduct are:firstly,Being more aware of legal consciousness;secondly,Quickening the lawmaking process on academic standards;thirdly,Strengthening the law enforcement on academic misconduct and the forth,Tightening up law enforcement to academic misconduct.

Health security measures of food and drinking water during military training on the plateau / 军事医学

Objective To investigate the health security requirements on food and drinking water during military training on the plateau,and explore ways to improve military health security support capability.Methods Seven army units were randomly chosen.By means of on-site check and sample detection,both internal and external environmental factor changes and health and safety conditions of food and drinking water were surveyed on the plateau.Internal and external standard methods were used to test the stability of portable instruments.Results There was considerable difference in diurnal temperature and relative humidity between indoors and outdoors.In two field units,raw materials of foods were purchased in a centralized manner and suppliers were fixed,they were purchased independently in the othev five units. Facilities of food storage and transportation were lacking in all the seven units.In one of the fifty-three food samples, residues of pesticides exceeded the national standard.Among the three water samples,the level of turbidity,ammonia nitrogen and nitrate nitrogen was lower than the standard limits,but free residual chlorine and total chlorine were not detected.The plateau environment had no significant effect on spectrophotometers,but had significant influence on enzyme-linked immune detectors.Conclusion There are potential health hazards to training troops on the plateau that arise from foods and drinking water.Improvement of management and equipment adaptability is needed to further enhance the field health security efficacy.

Repeated dose toxicity of Tangwang Mingmu granules in Sprague-Dawley rats / 军事医学

Objective To observe toxic symptoms and signs , toxic damage extents and reversibility in rats after oral administration of Tangwang Mingmu granules .Methods Four dose groups with 40 rats in each group were designed in this study, including control group fed with distilled water and three groups at different dosages of the test drug .Tangwang Mingmu granules were orally administered to SD rats at the dosage of 8.4, 4.2 and 2.1 g/kg for 3 weeks and 14.0, 8.4 and 4.2 g/kg for 23 weeks, for 26 consecutive weeks .The general state of the rats was observed every day , while body mass and food consumption were calculated once a week .Halfway through and at the end of the administration (13 and 26 weeks) and after four weeks of recovery, parameters of body mass, hematology, hematological biochemistry, organ/body mass ratio and histopathology were measured .Results Compared with the control group at the same time-point, body mass of male rats in the other three groups was slightly reduced .Food consumption in high and medium dose groups was reduced (P<0.05), MCHC, ALT, TBIL and Na +in high dose group were decreased (P<0.05), TP, ALB and D-BIL were increased (P<0.05), the mean body mass and relative organ weight of thymus in medium dose male rats were decreased (P<0.05), relative organ weight of the liver and kidney in high dose male rats was increased (P<0.05), and focal chronic inflammation to different extent was observed in the liver , kidney and prostate gland .No dose-effect relationship was found in these perturbations that were all within the normal range of animals .No significant drug-related pathological changes were found.Conclusion The NOAEL of Tangwang Mingmu granules is considered to be 14.0 g/kg body mass/day (equal to 50 times the proposed clinical adult dosage ) for the 26-week repeated dose oral toxicity study in male andfemale rats.

Establishment of normal reference ranges for clinical pathology indexes of Beagle dogs in GLP system / 军事医学

Objective To establish the normal reference ranges of clinical pathology for Beagle dogs in the Good Laboratory Practice ( GLP ) system.Method Sixteen biochemical indexes , seventeen hematological indexs and three coagulation function indexes of 117 Beagle dogs were detected , and the mean value of each index and the normal reference ranges were calculated and compared .Results Only alkaline phosphatase ( ALP ) from the biochemical items was significantly different between males and females (P<0.01),which was higher among males than among females .Three in-dexes of hematology were significantly different between males and females (P<0.01),with red blood cell(RBC), hemo-globin(HGB)and hematocrit(HCT)lower among males than among females.The coagulation function items were not signif-icantly different between the two sexes .Conclusion Some indexes of clinical pathology were significantly different between males and females , which should be considered during statistic analysis on toxicity .Our study has established the normal reference range of clinical pathology for Beagle dogs in the GLP system , which provides reference for toxicity tests .

T-2 toxin inhibits mitochondrial function of differentiated murine embryonic stem cells / 中国药理学与毒理学杂志

OBJECTIVE ToexplorethepossiblemechanismoractiontargetsofT-2toxinembryo toxicity by observing the effect of T-2 toxin on mitochondrial function of differentiated murine e mbryonic stemcells(mESCs).METHODS Duringdifferentiationat24,72and120h,ESCswereexposedto T-2 toxin 0.5 μg·L-1 .Meanwhile,mESCs were pre-treated with antioxidant Trolox (200 μmol·L-1 )for 30 min and exposed to T-2 toxin (0.5 μg·L-1 )for 72 h.The mitochondrial ultrasture of differentiated mESCs was observed under a transi mission electrical microscope (TEM).The differentiated ESC mito-chondrial function,including respiratory control ratio (RCR),ATP synthase activity and mitochondrial membranepotential(MMP),wasmeasuredat144hafterdifferentiation.RESULTS Significant decrease of the mitochondrial number,deformation of mitochondrial structure,and lack of complete mito-chodrial crest were observed through TEM in the groups of T-2 toxin exposed for 72 and 1 20 h,respec-tively.Compared with the normal control group,RCR declined by 49.5% and 55.1%,ATP synthase activity decreased by 84.9% and 89.3%,and MMP decreased by 23.2% and 35.2% in T-2 toxin 0.5 μg·L-1 exposure 72 and 1 20 h group,respectively.However,the inhibition of mitochondrial function by T-2 toxin in differentiated mESCs recovered significantly in the presence of the antioxidant Trolox. CONCLUSION T-2toxininducesoxidativestressandinhibitsmESCsmitochondrialfunctionindifferenti-ated mESCs,and ROS-induced mitochondrial malfunction plays an i mportant role in T-2 toxin e mbryonic toxicity mechanis m.

Study on the treatment of severe hypertensive cerebral hemorrhage by the operation with integrative needle and drill / 中国医师进修杂志

Objective To observe the effect of severe hypertensive cerebral hemorrhage with minimally invasive technology. Method Fifty patients of severe hypertensive cerebral hemorrhage treated by minimally invasive puncture combined early systemic rehabilitation (treatment group), and 49 patients with conventional treatment as control group. Results (1)The survival number were 37 cases in treatment group and 28 cases in control group. The survival patients with GCS after 4 weeks in treatment group was significantly higher than that in control group (P < 0.01). (2) FIM score of treatment group and control group on admission [(58±12) scores vs (60±11) scores] and the 14 th day [(64±13) scores vs (62±12) scores] after treatment, there was no significant difference (P > 0.05), but the FIM score of treatment group at the first month [(76±16) scores vs (65±14) scores] and the third month [(90±22) scores vs (69±18) scores] after treatment were significantly superior to eontrol group (P < 0.05). (3) NIHSS score of treatment group and control group on admission were (17.5±3.5) scores and (16.9±3.4) scores (P > 0.05), the NIHSS score of treatment group at the 14th day,the first month and the third month were significantly superior to control group [(14.3±3.3) scores vs (16.2±3.5) scores, (12.1±2.4) scores vs (15.7±3.4) scores, (9.0±3.4) scores vs(12.2±23.6) scores, respectively] (P< 0.05). Conclusion The treatment of severe hypertensive cerebral hemorrhage with minimally invasive percutaneous is safe and effective, the effect is superior to conventional medical treatment.

Effects of taurine on left ventricular hypertrophy in renovascular hypertensive rats / 中国药理学通报

AIM To investigate the preventive effects of taurine on the left ventricle hypertrophy in renovascular hypertensive rats. METHODS Two-kidney 1-clip (2K1C) rats were used to establish the model of renovascular hypertension. The myocardial local aldosterone(Ald) and AngⅡconcentration (MDC,MAC) were measured by radioimmunoassay. Expression of oncogene c-fos mRNA was analyzed by means of in situ hybridization. The myocardial collagen concentration (MCC) was measured by biochemical method. The myocardial tissue structure was observed under the microscope ,and the myocardial fiber diamension (MFD) was measured with micrometer. The linear correlation between MCC, MFD and MAC or MDC was analysed respectively. RESULTS Compared with sham operated rats ,the MCC, MAC, MDC and MFD were significantly increased in 2K1C rats ( P